In Vitro and In Vivo Evaluation of Voriconazole-Containing Antifungal Combinations against Mucorales Using a Galleria mellonella Model of Mucormycosis

In Vitro and In Vivo Evaluation of Voriconazole-Containing Antifungal Combinations against Mucorales Using a Galleria mellonella Model of Mucormycosis

Mucorales are resistant to most antifungals. Mucormycosis associated mortality is unacceptable and new treatment approaches are needed. The objectives of this work were (i) to evaluate the nature and intensity of the in vitro effect of three drugs combinations which included voriconazole (plus ampho...

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Bibliographic Details
Main Authors: Daiana Macedo, Florencia Leonardelli, Catiana Dudiuk, Roxana G. Vitale, Eleodoro Del Valle, Gustavo Giusiano, Soledad Gamarra, Guillermo Garcia-Effron
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Journal of Fungi
Subjects:
mucormycosis
Galleria mellonella
synergism
azole
voriconazole
amphotericin B
Online Access:http://www.mdpi.com/2309-608X/5/1/5

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