Effects of Sulfaphenazole Derivatives on Cardiac Ischemia–Reperfusion Injury: Association of Cytochrome P450 Activity and Infarct Size

Effects of Sulfaphenazole Derivatives on Cardiac Ischemia–Reperfusion Injury: Association of Cytochrome P450 Activity and Infarct Size

Cardiac ischemia–reperfusion injury is evoked by reactive oxygen species (ROS). We previously reported that sulfaphenazole (SPZ) attenuated cardiac ROS levels and ischemia–reperfusion injury in rats. SPZ has distinct two actions: a) elimination of ROS and b) inhibition of cytochrome P450 (CYP) that...

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Bibliographic Details
Main Authors: Yasuhiro Ishihara, Masaya Sekine, Ai Hamaguchi, Yusuke Kobayashi, Takashi Harayama, Mikio Nakazawa, Norio Shimamoto
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319309004

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