A Simple and Green Protocol for the Synthesis of 3,4-dihydropyrimidin-2(1H)-ones Using 11-Molybdo-1-vanado phosphoric Acid as a Catalyst Under Ultrasound Irradiation

• Main Authors: Laxmikant Dnyaneshwar Chavan, Surekha Narayanrao Deshmukh, Sunil G. Shankarwar
• Format: Article
• Language: English
• Published: Universidade Federal de Mato Grosso do Sul 2019-10-01
• Series: Orbital: The Electronic Journal of Chemistry
• Subjects: 3,4-dihydropyrimidin-2(1h)-ones; heteropoly acids; 11-molybdo-1-vanadophosphoric acid; ultrasound irradiation
• Online Access: http://orbital.ufms.br/index.php/Chemistry/article/view/1423

<p class="orbitalabstract">A one-pot three-component reaction of ethyl acetoacetate, aldehydes and urea has efficiently been carried out in the presence of 11-molybdo-1-vanadophosphoric acid in ethanol at room temperature under ultrasound irradiation to form the corresponding 3,4-dihydropyrimidin 2(1H)-ones in high yields. The 11-molybdo-1-vanadophosphoric acid (H₄PMo₁₁V₁O₄₀) was prepared and characterized by FT-IR spectroscopy, TG-DTA analysis and XRD analysis techniques. The presence of Keggin structure and incorporation of vanadium into the Keggin structure of synthesized H₄PMo₁₁V₁O₄₀catalyst was confirmed by FT-IR and powder XRD analysis techniques. TG-DTA analysis results indicated that H₄PMo₁₁V₁O₄₀ catalyst was thermally stable up to the temperature 434 °C. The present catalytic system is recyclable and can be reused without greater loss of reactivity.</p><p class="orbitalabstract"> </p><p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v11i5.1423">http://dx.doi.org/10.17807/orbital.v11i5.1423</a></p><p> </p> <p> </p>