Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling.

Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling.

SHARPIN is a key regulator of NFKB and integrin signaling. Mice lacking Sharpin develop a phenotype known as chronic proliferative dermatitis (CPDM), typified by progressive epidermal hyperplasia, apoptosis of keratinocytes, cutaneous and systemic eosinophilic inflammation, and hypoplasia of seconda...

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Bibliographic Details
Main Authors: Christopher S Potter, Zhe Wang, Kathleen A Silva, Victoria E Kennedy, Timothy M Stearns, Lisa Burzenski, Leonard D Shultz, Harm Hogenesch, John P Sundberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897490?pdf=render

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http://europepmc.org/articles/PMC3897490?pdf=render

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