The changing role of radiation therapy in the management of oligometastatic disease

The changing role of radiation therapy in the management of oligometastatic disease

It is clear from surgical series that there are selected patients presenting with localised metastatic disease who can be cured by radical ablation of the metastasis. To date this has been limited to surgical resection but the evolution of stereotactic ablative body radiotherapy (SABR) has opened ne...

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Main Authors: H. Tharmalingham, P.J. Hoskin
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Technical Innovations & Patient Support in Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405632417300021
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spelling doaj-32cd43450d8c43fc8ef373d7d19efaa62020-11-24T21:56:00ZengElsevierTechnical Innovations & Patient Support in Radiation Oncology2405-63242017-03-0111315The changing role of radiation therapy in the management of oligometastatic diseaseH. Tharmalingham0P.J. Hoskin1Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN, United KingdomCorresponding author.; Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN, United KingdomIt is clear from surgical series that there are selected patients presenting with localised metastatic disease who can be cured by radical ablation of the metastasis. To date this has been limited to surgical resection but the evolution of stereotactic ablative body radiotherapy (SABR) has opened new opportunities. Hypofractionated radiation delivery in 1 to 5 fractions can achieve durable local control with low toxicity. The focus is now to develop robust biomarkers so that those with true oligometastatic and thereby potentially curable disease can be selected for this approach. Keywords: Oligometastases, Stereotactic ablative body radiotherapy (SABR), Biomarkershttp://www.sciencedirect.com/science/article/pii/S2405632417300021
collection DOAJ
language English
format Article
sources DOAJ
author H. Tharmalingham
P.J. Hoskin
spellingShingle H. Tharmalingham
P.J. Hoskin
The changing role of radiation therapy in the management of oligometastatic disease
Technical Innovations & Patient Support in Radiation Oncology
author_facet H. Tharmalingham
P.J. Hoskin
author_sort H. Tharmalingham
title The changing role of radiation therapy in the management of oligometastatic disease
title_short The changing role of radiation therapy in the management of oligometastatic disease
title_full The changing role of radiation therapy in the management of oligometastatic disease
title_fullStr The changing role of radiation therapy in the management of oligometastatic disease
title_full_unstemmed The changing role of radiation therapy in the management of oligometastatic disease
title_sort changing role of radiation therapy in the management of oligometastatic disease
publisher Elsevier
series Technical Innovations & Patient Support in Radiation Oncology
issn 2405-6324
publishDate 2017-03-01
description It is clear from surgical series that there are selected patients presenting with localised metastatic disease who can be cured by radical ablation of the metastasis. To date this has been limited to surgical resection but the evolution of stereotactic ablative body radiotherapy (SABR) has opened new opportunities. Hypofractionated radiation delivery in 1 to 5 fractions can achieve durable local control with low toxicity. The focus is now to develop robust biomarkers so that those with true oligometastatic and thereby potentially curable disease can be selected for this approach. Keywords: Oligometastases, Stereotactic ablative body radiotherapy (SABR), Biomarkers
url http://www.sciencedirect.com/science/article/pii/S2405632417300021
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