3D-QSAR Study of Potent Inhibitors of Phosphodiesterase-4 Using a CoMFA Approach

3D-QSAR Study of Potent Inhibitors of Phosphodiesterase-4 Using a CoMFA Approach

Phosphodiesterase-4 (PDE4) plays an important role in treatment of asthma andchronic obstructive pulmonary disease. Thirty-one analogs displaying variable inhibition ofPDE4 were selected to develop models for establishing three-dimensional quantitativestructure-activity relationships (3D-QSAR). Comp...

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Bibliographic Details
Main Authors: Pinghua Sun, Zhaoqi Yang
Format: Article
Language:English
Published: MDPI AG 2007-07-01
Series:International Journal of Molecular Sciences
Subjects:
QSAR
CoMFA
Phosphodiesterase-4
Online Access:http://www.mdpi.com/1422-0067/8/7/714/

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http://www.mdpi.com/1422-0067/8/7/714/

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