MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.

MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.

Mutations in mitochondrial replicative polymerase PolγA lead to progressive external ophthalmoplegia (PEO). While PolγA is the known central player in mitochondrial DNA (mtDNA) replication, it is unknown whether a regulatory process exists on the mitochondrial outer membrane which controlled its ent...

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Bibliographic Details
Main Authors: Mansoor Hussain, Aftab Mohammed, Shabnam Saifi, Aamir Khan, Ekjot Kaur, Swati Priya, Himanshi Agarwal, Sagar Sengupta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001139

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