Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Abstract Background Rheumatoid arthritis is a common autoimmune disorder influenced by both genetic and environmental factors. Epigenome-wide association studies can identify environmentally mediated epigenetic changes such as altered DNA methylation, which may also be influenced by genetic factors....

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Bibliographic Details
Main Authors: Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Medicine
Subjects:
Autoimmune disease
Rheumatoid arthritis
Epigenetics
DNA methylation
Twins
Online Access:http://link.springer.com/article/10.1186/s13073-018-0575-9

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