Effective gene editing by high-fidelity base editor 2 in mouse zygotes

Effective gene editing by high-fidelity base editor 2 in mouse zygotes

ABSTRACT Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease-causing mutations in patients. However, problems such as mosaicism and low mutagenesis efficiency continue to pose challenges to clinical...

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Bibliographic Details
Main Authors: Puping Liang, Hongwei Sun, Ying Sun, Xiya Zhang, Xiaowei Xie, Jinran Zhang, Zhen Zhang, Yuxi Chen, Chenhui Ding, Yuanyan Xiong, Wenbin Ma, Dan Liu, Junjiu Huang, Zhou Songyang
Format: Article
Language:English
Published: SpringerOpen 2017-06-01
Series:Protein & Cell
Subjects:
base editor
high-fidelity
mouse embryos
proximal-site deamination
whole-genome sequencing
Online Access:http://link.springer.com/article/10.1007/s13238-017-0418-2

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