Early antiinflammatory therapy attenuates brain damage after sah in rats

Early antiinflammatory therapy attenuates brain damage after sah in rats

Early inflammatory processes may play an important role in the development of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Experimental studies suggest that anti-inflammatory and membrane-stabilizing drugs might have beneficial effects, although the underlying mechanisms are not ful...

Full description

Bibliographic Details
Main Authors: Vadokas Georg, Koehler Stefan, Weiland Judith, Lilla Nadine, Stetter Christian, Westermaier Thomas
Format: Article
Language:English
Published: De Gruyter 2019-04-01
Series:Translational Neuroscience
Subjects:
subarachnoid hemorrhage
early brain injury
methylprednisolone
minocycline
neuroprotection
Online Access:https://doi.org/10.1515/tnsci-2019-0018
id doaj-32a92fd4b3ca47faad48fac7b8e4d207
record_format Article
spelling doaj-32a92fd4b3ca47faad48fac7b8e4d2072021-09-05T20:51:31ZengDe GruyterTranslational Neuroscience2081-69362019-04-0110110411110.1515/tnsci-2019-0018tnsci-2019-0018Early antiinflammatory therapy attenuates brain damage after sah in ratsVadokas Georg0Koehler Stefan1Weiland Judith2Lilla Nadine3Stetter Christian4Westermaier Thomas5Department of Neurosurgery, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080Würzburg, GermanyDepartment of Neurosurgery, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080Würzburg, GermanyDepartment of Neurosurgery, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080Würzburg, GermanyDepartment of Neurosurgery, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080Würzburg, GermanyDepartment of Neurosurgery, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080Würzburg, GermanyDepartment of Neurosurgery, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080Würzburg, GermanyEarly inflammatory processes may play an important role in the development of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Experimental studies suggest that anti-inflammatory and membrane-stabilizing drugs might have beneficial effects, although the underlying mechanisms are not fully understood. The aim of this study was to investigate the effect of early treatment with methylprednisolone and minocycline on cerebral perfusion and EBI after experimental SAH.https://doi.org/10.1515/tnsci-2019-0018subarachnoid hemorrhageearly brain injurymethylprednisoloneminocyclineneuroprotection
collection DOAJ
language English
format Article
sources DOAJ
author Vadokas Georg
Koehler Stefan
Weiland Judith
Lilla Nadine
Stetter Christian
Westermaier Thomas
spellingShingle Vadokas Georg
Koehler Stefan
Weiland Judith
Lilla Nadine
Stetter Christian
Westermaier Thomas
Early antiinflammatory therapy attenuates brain damage after sah in rats
Translational Neuroscience
subarachnoid hemorrhage
early brain injury
methylprednisolone
minocycline
neuroprotection
author_facet Vadokas Georg
Koehler Stefan
Weiland Judith
Lilla Nadine
Stetter Christian
Westermaier Thomas
author_sort Vadokas Georg
title Early antiinflammatory therapy attenuates brain damage after sah in rats
title_short Early antiinflammatory therapy attenuates brain damage after sah in rats
title_full Early antiinflammatory therapy attenuates brain damage after sah in rats
title_fullStr Early antiinflammatory therapy attenuates brain damage after sah in rats
title_full_unstemmed Early antiinflammatory therapy attenuates brain damage after sah in rats
title_sort early antiinflammatory therapy attenuates brain damage after sah in rats
publisher De Gruyter
series Translational Neuroscience
issn 2081-6936
publishDate 2019-04-01
description Early inflammatory processes may play an important role in the development of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Experimental studies suggest that anti-inflammatory and membrane-stabilizing drugs might have beneficial effects, although the underlying mechanisms are not fully understood. The aim of this study was to investigate the effect of early treatment with methylprednisolone and minocycline on cerebral perfusion and EBI after experimental SAH.
topic subarachnoid hemorrhage
early brain injury
methylprednisolone
minocycline
neuroprotection
url https://doi.org/10.1515/tnsci-2019-0018
work_keys_str_mv AT vadokasgeorg earlyantiinflammatorytherapyattenuatesbraindamageaftersahinrats
AT koehlerstefan earlyantiinflammatorytherapyattenuatesbraindamageaftersahinrats
AT weilandjudith earlyantiinflammatorytherapyattenuatesbraindamageaftersahinrats
AT lillanadine earlyantiinflammatorytherapyattenuatesbraindamageaftersahinrats
AT stetterchristian earlyantiinflammatorytherapyattenuatesbraindamageaftersahinrats
AT westermaierthomas earlyantiinflammatorytherapyattenuatesbraindamageaftersahinrats
_version_ 1717783624386871296

Similar Items