Early antiinflammatory therapy attenuates brain damage after sah in rats

Early antiinflammatory therapy attenuates brain damage after sah in rats

Early inflammatory processes may play an important role in the development of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Experimental studies suggest that anti-inflammatory and membrane-stabilizing drugs might have beneficial effects, although the underlying mechanisms are not ful...

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Bibliographic Details
Main Authors: Vadokas Georg, Koehler Stefan, Weiland Judith, Lilla Nadine, Stetter Christian, Westermaier Thomas
Format: Article
Language:English
Published: De Gruyter 2019-04-01
Series:Translational Neuroscience
Subjects:
subarachnoid hemorrhage
early brain injury
methylprednisolone
minocycline
neuroprotection
Online Access:https://doi.org/10.1515/tnsci-2019-0018
Description
Summary:Early inflammatory processes may play an important role in the development of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Experimental studies suggest that anti-inflammatory and membrane-stabilizing drugs might have beneficial effects, although the underlying mechanisms are not fully understood. The aim of this study was to investigate the effect of early treatment with methylprednisolone and minocycline on cerebral perfusion and EBI after experimental SAH.
ISSN:2081-6936

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