Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-catenin

Nek2B activates the wnt pathway and promotes triple-negative breast cancer chemothezrapy-resistance by stabilizing β-catenin

Abstract Background The chemotherapy-resistance of triple-negative breast cancer (TNBC) remains a major challenge. The Nek2B kinase and β-catenin serve as crucial regulators of mitotic processes. The aim of this study was to test the correlation between Nek2B and TNBC chemotherapy sensitivity, and t...

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Bibliographic Details
Main Authors: Honghong Shen, Wenpeng Yan, Jinyang Yuan, Ziyue Wang, Chen Wang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Nek2B
β-Catenin
Wnt signaling pathway
Triple-negative breast cancer
Chemotherapy resistance
Online Access:http://link.springer.com/article/10.1186/s13046-019-1231-y

Internet

http://link.springer.com/article/10.1186/s13046-019-1231-y

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