Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway

Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway

Abstract Patients with osteosarcoma exhibiting resistance to chemotherapy or presenting with metastasis usually have a poor prognosis. Osteosarcoma stem cells (OSCs) are a potential cause of tumor metastasis, relapse, and chemotherapy resistance. Therefore, it is necessary to develop novel therapeut...

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Bibliographic Details
Main Authors: Shangyu Wang, Hongzhi Hu, Binlong Zhong, Deyao Shi, Xiangcheng Qing, Cheng Cheng, Xiangyu Deng, Zhicai Zhang, Zengwu Shao
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Cancer Medicine
Subjects:
bruceine D
cancer stem cells
osteosarcoma
STAT3 signaling pathway
Online Access:https://doi.org/10.1002/cam4.2612

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