Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus

Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus

Pleurotus feruleus is an edible and medicinal mushroom. We previously demonstrated that the crude and purified polysaccharides from cultivated P. feruleus (PFCP-C and PFPS-C) had the immunostimulatory activity. Here, the crude and purified polysaccharides of wild P. feruleus (PFCP-W and PFPS-W) were...

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Main Authors: Pengfei Yuan, Adila Aipire, Yi Yang, Xianxian Wei, Changshuang Fu, Fangfang Zhou, Mahepali Mahabati, Jinyu Li, Jinyao Li
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Journal of Functional Foods
Subjects:
Pleurotus feruleus
Polysaccharides
Dendritic cell
Immunostimulatory activity
TLR4 signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620302747
id doaj-3292e81887a949ae832de38174878c37
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spelling doaj-3292e81887a949ae832de38174878c372021-04-30T07:19:12ZengElsevierJournal of Functional Foods1756-46462020-09-0172104050Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleusPengfei Yuan0Adila Aipire1Yi Yang2Xianxian Wei3Changshuang Fu4Fangfang Zhou5Mahepali Mahabati6Jinyu Li7Jinyao Li8Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaCollege of Life Science, Xinjiang Normal University, Urumqi 830054, China; Corresponding authors at: Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China (J. Li).Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China; Affliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011, China; Corresponding authors at: Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China (J. Li).Pleurotus feruleus is an edible and medicinal mushroom. We previously demonstrated that the crude and purified polysaccharides from cultivated P. feruleus (PFCP-C and PFPS-C) had the immunostimulatory activity. Here, the crude and purified polysaccharides of wild P. feruleus (PFCP-W and PFPS-W) were compared with PFCP-C and PFPS-C on the immunostimulatory activity. PFCP-W and PFCP-C showed similar activity on dendritic cell (DC) maturation in vitro, whereas the activity of PFCP-W was higher than that of PFCP-C in vivo. The monosaccharide compositions of PFPS-W and PFPS-C were different. PFPS-W was sulfated polysaccharides with crude surface. PFPS-W and PFPS-C promoted the activation of DCs and macrophages through TLR4 signaling pathway, whereas the activity of PFPS-W was higher than that of PFPS-C. The maturation and migration of DCs in vivo were significantly increased by PFPS-W and PFPS-C. Moreover, PFPS-W and PFPS-C significantly enhanced the antigen-specific cellular immune responses induced by DC-based vaccine.http://www.sciencedirect.com/science/article/pii/S1756464620302747Pleurotus feruleusPolysaccharidesDendritic cellImmunostimulatory activityTLR4 signaling pathway
collection DOAJ
language English
format Article
sources DOAJ
author Pengfei Yuan
Adila Aipire
Yi Yang
Xianxian Wei
Changshuang Fu
Fangfang Zhou
Mahepali Mahabati
Jinyu Li
Jinyao Li
spellingShingle Pengfei Yuan
Adila Aipire
Yi Yang
Xianxian Wei
Changshuang Fu
Fangfang Zhou
Mahepali Mahabati
Jinyu Li
Jinyao Li
Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus
Journal of Functional Foods
Pleurotus feruleus
Polysaccharides
Dendritic cell
Immunostimulatory activity
TLR4 signaling pathway
author_facet Pengfei Yuan
Adila Aipire
Yi Yang
Xianxian Wei
Changshuang Fu
Fangfang Zhou
Mahepali Mahabati
Jinyu Li
Jinyao Li
author_sort Pengfei Yuan
title Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus
title_short Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus
title_full Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus
title_fullStr Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus
title_full_unstemmed Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus
title_sort comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated pleurotus feruleus
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2020-09-01
description Pleurotus feruleus is an edible and medicinal mushroom. We previously demonstrated that the crude and purified polysaccharides from cultivated P. feruleus (PFCP-C and PFPS-C) had the immunostimulatory activity. Here, the crude and purified polysaccharides of wild P. feruleus (PFCP-W and PFPS-W) were compared with PFCP-C and PFPS-C on the immunostimulatory activity. PFCP-W and PFCP-C showed similar activity on dendritic cell (DC) maturation in vitro, whereas the activity of PFCP-W was higher than that of PFCP-C in vivo. The monosaccharide compositions of PFPS-W and PFPS-C were different. PFPS-W was sulfated polysaccharides with crude surface. PFPS-W and PFPS-C promoted the activation of DCs and macrophages through TLR4 signaling pathway, whereas the activity of PFPS-W was higher than that of PFPS-C. The maturation and migration of DCs in vivo were significantly increased by PFPS-W and PFPS-C. Moreover, PFPS-W and PFPS-C significantly enhanced the antigen-specific cellular immune responses induced by DC-based vaccine.
topic Pleurotus feruleus
Polysaccharides
Dendritic cell
Immunostimulatory activity
TLR4 signaling pathway
url http://www.sciencedirect.com/science/article/pii/S1756464620302747
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