β1-Blockers Enhance Inotropy of Endogenous Catecholamines in Chronic Heart Failure

β1-Blockers Enhance Inotropy of Endogenous Catecholamines in Chronic Heart Failure

Although β1-blockers impressively reduce mortality in chronic heart failure (CHF), there are concerns about negative inotropic effects and worsening of hemodynamics in acute decompensated heart failure. May receptor theory dispel these concerns and confirm clinical practice to use β1-blockers? In CH...

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Bibliographic Details
Main Authors: Thomas J. Feuerstein, Eberhard Schlicker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
chronic heart failure
sympathetic tone
homodimer
negative cooperativity
binomial distribution
receptor reserve
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.639562/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.639562/full

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