Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens

Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens

Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors. Quorum sensing is a particularly attractive target because several bacterial virulence factors are controlled by this mechanism. Furthermore,...

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Bibliographic Details
Main Authors: Osmel Fleitas Martínez, Pietra Orlandi Rigueiras, Állan da Silva Pires, William Farias Porto, Osmar Nascimento Silva, Cesar de la Fuente-Nunez, Octavio Luiz Franco
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
virulence
antibiotic resistance
quorum sensing
quorum-sensing inhibition
anti-virulence therapy
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00444/full

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