An extremely rare case of concurrent BRAF V600E mutation driven hairy cell leukemia and melanoma: case report and review of literature

An extremely rare case of concurrent BRAF V600E mutation driven hairy cell leukemia and melanoma: case report and review of literature

BRAF protein is a serine/threonine kinase with 766 amino acids. Approximately 15% of human cancers harbor BRAF mutations as well as other BRAF anomalies (amplifications, fusions). Somatic mutations mainly occur in the catalytic kinase domain (CR3), and the predominant mutation is p.V600E which is th...

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Bibliographic Details
Main Authors: Amir Ghorbani-Aghbolaghia, Mirna Lechpammer, Saba F. Ali, Nam K. Ku, Denis M. Dwyre, Hooman H. Rashidi
Format: Article
Language:English
Published: University of São Paulo 2017-09-01
Series:Autopsy and Case Reports
Subjects:
Leukemia
Hairy Cell
Melanoma
Proto-Oncogene Proteins B-raf
Online Access:http://www.revistas.usp.br/autopsy/article/view/139572

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