Antifibrotic role of low-dose mitomycin-c-induced cellular senescence in trabeculectomy models.

Antifibrotic role of low-dose mitomycin-c-induced cellular senescence in trabeculectomy models.

<h4>Purpose</h4>We assessed whether mitomycin-C (MMC) has different antifibrotic mechanisms in trabeculectomy wound healing.<h4>Methods</h4>We identified 2 concentrations of MMC as "low-dose" by using WST-1 assay, Lactic dehydrogenase assay, and fluorescence-activat...

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Main Authors: Le-Tien Lin, Jiann-Torng Chen, Da-Wen Lu, Ming-Cheng Tai, Chang-Min Liang, Ching-Long Chen, Shu-I Pao, Chih-Kang Hsu, Yi-Hao Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0234706

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