| Summary: | The purpose of this study resides in the design and deposition of several types of bioactive interfaces with complex composition, targeting a superior osseointegration of bone implants. The experimental approach is framed by two oxide systems, SiO<sub>2</sub>‒CaO‒P<sub>2</sub>O<sub>5</sub>‒ZnO‒MgO and SiO<sub>2</sub>‒CaO‒P<sub>2</sub>O<sub>5</sub>‒ZnO‒SrO, while the percentage values were established as optimised solutions for ensuring wear resistance, bioactivity and beneficial effects on cell metabolism and reproduction. Moreover, two methods dedicated to fils growth (pulsed laser deposition and spin coating) were explored as potential variants for coating the bioinert materials and providing a transitional anchoring layer between the artificial substitute and host tissue. The obtained layers were evaluated as vitroceramic in nature, nanostructured in morphology and bioactive in relation to the physiological environment. The response of human fetal osteoblasts placed in contact with the new engineered surfaces was characterized by a significant proliferation from 1 to 4 days, which validates their suitability for hard tissue applications.
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