Bleeding Disorders in Primary Fibrinolysis

Fibrinolysis is a complex enzymatic process aimed at dissolving blood clots to prevent vascular occlusions. The fibrinolytic system is composed of a number of cofactors that, by regulating fibrin degradation, maintain the hemostatic balance. A dysregulation of fibrinolysis is associated with various...

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Main Authors:	Massimo Franchini, Marco Zaffanello, Pier Mannuccio Mannucci
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	International Journal of Molecular Sciences
Subjects:	primary hyperfibrinolysis bleeding hemorrhage inherited acquired
Online Access:	https://www.mdpi.com/1422-0067/22/13/7027

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spelling	doaj-3257777d8a494680ac480480d9d1817a2021-07-15T15:37:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01227027702710.3390/ijms22137027Bleeding Disorders in Primary FibrinolysisMassimo Franchini0Marco Zaffanello1Pier Mannuccio Mannucci2Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, 46100 Mantova, ItalyDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37126 Verona, ItalyAngelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico and University of Milan, 20122 Milan, ItalyFibrinolysis is a complex enzymatic process aimed at dissolving blood clots to prevent vascular occlusions. The fibrinolytic system is composed of a number of cofactors that, by regulating fibrin degradation, maintain the hemostatic balance. A dysregulation of fibrinolysis is associated with various pathological processes that result, depending on the type of abnormality, in prothrombotic or hemorrhagic states. This narrative review is focused on the congenital and acquired disorders of primary fibrinolysis in both adults and children characterized by a hyperfibrinolytic state with a bleeding phenotype.https://www.mdpi.com/1422-0067/22/13/7027primary hyperfibrinolysisbleedinghemorrhageinheritedacquired
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Massimo Franchini Marco Zaffanello Pier Mannuccio Mannucci
spellingShingle	Massimo Franchini Marco Zaffanello Pier Mannuccio Mannucci Bleeding Disorders in Primary Fibrinolysis International Journal of Molecular Sciences primary hyperfibrinolysis bleeding hemorrhage inherited acquired
author_facet	Massimo Franchini Marco Zaffanello Pier Mannuccio Mannucci
author_sort	Massimo Franchini
title	Bleeding Disorders in Primary Fibrinolysis
title_short	Bleeding Disorders in Primary Fibrinolysis
title_full	Bleeding Disorders in Primary Fibrinolysis
title_fullStr	Bleeding Disorders in Primary Fibrinolysis
title_full_unstemmed	Bleeding Disorders in Primary Fibrinolysis
title_sort	bleeding disorders in primary fibrinolysis
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1661-6596 1422-0067
publishDate	2021-06-01
description	Fibrinolysis is a complex enzymatic process aimed at dissolving blood clots to prevent vascular occlusions. The fibrinolytic system is composed of a number of cofactors that, by regulating fibrin degradation, maintain the hemostatic balance. A dysregulation of fibrinolysis is associated with various pathological processes that result, depending on the type of abnormality, in prothrombotic or hemorrhagic states. This narrative review is focused on the congenital and acquired disorders of primary fibrinolysis in both adults and children characterized by a hyperfibrinolytic state with a bleeding phenotype.
topic	primary hyperfibrinolysis bleeding hemorrhage inherited acquired
url	https://www.mdpi.com/1422-0067/22/13/7027
work_keys_str_mv	AT massimofranchini bleedingdisordersinprimaryfibrinolysis AT marcozaffanello bleedingdisordersinprimaryfibrinolysis AT piermannucciomannucci bleedingdisordersinprimaryfibrinolysis
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Bleeding Disorders in Primary Fibrinolysis

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