Peptides and Dendrimers: How to Combat Viral and Bacterial Infections

Peptides and Dendrimers: How to Combat Viral and Bacterial Infections

The alarming growth of antimicrobial resistance and recent viral pandemic events have enhanced the need for novel approaches through innovative agents that are mainly able to attach to the external layers of bacteria and viruses, causing permanent damage. Antimicrobial molecules are potent broad-spe...

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Bibliographic Details
Main Authors: Annarita Falanga, Valentina Del Genio, Stefania Galdiero
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
peptide
dendrimer
antimicrobial
Online Access:https://www.mdpi.com/1999-4923/13/1/101
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spelling doaj-32550feffc664fb3bd9c063531d01e3c2021-01-15T00:04:37ZengMDPI AGPharmaceutics1999-49232021-01-011310110110.3390/pharmaceutics13010101Peptides and Dendrimers: How to Combat Viral and Bacterial InfectionsAnnarita Falanga0Valentina Del Genio1Stefania Galdiero2Department of Agricultural Science, University of Naples “Federico II”, via dell’Università, 100, 80100 Portici, ItalyDepartment of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano, 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano, 49, 80131 Naples, ItalyThe alarming growth of antimicrobial resistance and recent viral pandemic events have enhanced the need for novel approaches through innovative agents that are mainly able to attach to the external layers of bacteria and viruses, causing permanent damage. Antimicrobial molecules are potent broad-spectrum agents with a high potential as novel therapeutics. In this context, antimicrobial peptides, cell penetrating peptides, and antiviral peptides play a major role, and have been suggested as promising solutions. Furthermore, dendrimers are to be considered as suitable macromolecules for the development of advanced nanosystems that are able to complement the typical properties of dendrimers with those of peptides. This review focuses on the description of nanoplatforms constructed with peptides and dendrimers, and their applications.https://www.mdpi.com/1999-4923/13/1/101peptidedendrimerantimicrobial
collection DOAJ
language English
format Article
sources DOAJ
author Annarita Falanga
Valentina Del Genio
Stefania Galdiero
spellingShingle Annarita Falanga
Valentina Del Genio
Stefania Galdiero
Peptides and Dendrimers: How to Combat Viral and Bacterial Infections
Pharmaceutics
peptide
dendrimer
antimicrobial
author_facet Annarita Falanga
Valentina Del Genio
Stefania Galdiero
author_sort Annarita Falanga
title Peptides and Dendrimers: How to Combat Viral and Bacterial Infections
title_short Peptides and Dendrimers: How to Combat Viral and Bacterial Infections
title_full Peptides and Dendrimers: How to Combat Viral and Bacterial Infections
title_fullStr Peptides and Dendrimers: How to Combat Viral and Bacterial Infections
title_full_unstemmed Peptides and Dendrimers: How to Combat Viral and Bacterial Infections
title_sort peptides and dendrimers: how to combat viral and bacterial infections
publisher MDPI AG
series Pharmaceutics
issn 1999-4923
publishDate 2021-01-01
description The alarming growth of antimicrobial resistance and recent viral pandemic events have enhanced the need for novel approaches through innovative agents that are mainly able to attach to the external layers of bacteria and viruses, causing permanent damage. Antimicrobial molecules are potent broad-spectrum agents with a high potential as novel therapeutics. In this context, antimicrobial peptides, cell penetrating peptides, and antiviral peptides play a major role, and have been suggested as promising solutions. Furthermore, dendrimers are to be considered as suitable macromolecules for the development of advanced nanosystems that are able to complement the typical properties of dendrimers with those of peptides. This review focuses on the description of nanoplatforms constructed with peptides and dendrimers, and their applications.
topic peptide
dendrimer
antimicrobial
url https://www.mdpi.com/1999-4923/13/1/101
work_keys_str_mv AT annaritafalanga peptidesanddendrimershowtocombatviralandbacterialinfections
AT valentinadelgenio peptidesanddendrimershowtocombatviralandbacterialinfections
AT stefaniagaldiero peptidesanddendrimershowtocombatviralandbacterialinfections
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