Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity

Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity

Endomucin (EMCN) is the type I transmembrane glycoprotein, mucin-like component of the endothelial cell glycocalyx. We have previously shown that EMCN is necessary for vascular endothelial growth factor (VEGF)-induced VEGF receptor 2 (VEGFR2) internalization and downstream signaling. To explore the...

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Bibliographic Details
Main Authors: Zhengping Hu, Issahy Cano, Kahira L. Saez-Torres, Michelle E. LeBlanc, Magali Saint-Geniez, Yin-Shan Ng, Pablo Argüeso, Patricia A. D’Amore
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
EMCN
glycosylation
angiogenesis
VEGF
VEGFR2
mucin
Online Access:https://www.mdpi.com/2073-4409/9/6/1413

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