New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4′- (1′,4′-dihydropyridine)] Derivatives

New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4′- (1′,4′-dihydropyridine)] Derivatives

Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-[indole-3,4′-(1′,4′-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the presence of a chiral base organocatalyst. The moder...

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Bibliographic Details
Main Authors: Fernando Auria-Luna, Eugenia Marqués-López, Somayeh Mohammadi, Roghayeh Heiran, Raquel P. Herrera
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
chiral base
enamine
isatylidene malononitrile
1,4-dihydropyridine
enantioselective
isatin
organocatalysis
spirooxindole
2-oxospiro-[indole-3,4′- (1′,4′-dihydropyridine)]
Online Access:http://www.mdpi.com/1420-3049/20/9/15807

Internet

http://www.mdpi.com/1420-3049/20/9/15807

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