Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex
Extracellular potassium concentration, [K+]o, is a major determinant of neuronal excitability. In the healthy brain, [K+]o levels are tightly controlled. During seizures, [K+]o increases up to 15 mM and is thought to cause seizures due to its depolarizing effect. Although astrocytes have been sugges...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-05-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996116302984 |