Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab

Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab

We report a 67 year old lady with Rheumatoid Arthritis (RA) and mild bronchiectasis (BE) whose treatment was escalated to Rituximab. Nine months after commencing Rituximab her lung sepsis worsened dramatically with repeated hospitalization, new sputum isolation of Stenotrophomonas maltophilia and Ps...

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Main Authors: K. Musameh, C.D. Campbell, R.M. Rutherford
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Respiratory Medicine Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213007119301649
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spelling doaj-3245ef8e59694ddbab7efa163d84fa0c2020-11-25T01:29:43ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-0128Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with RituximabK. Musameh0C.D. Campbell1R.M. Rutherford2Corresponding author.; Department of Respiratory Medicine, University Hospital Galway, Galway, IrelandDepartment of Respiratory Medicine, University Hospital Galway, Galway, IrelandDepartment of Respiratory Medicine, University Hospital Galway, Galway, IrelandWe report a 67 year old lady with Rheumatoid Arthritis (RA) and mild bronchiectasis (BE) whose treatment was escalated to Rituximab. Nine months after commencing Rituximab her lung sepsis worsened dramatically with repeated hospitalization, new sputum isolation of Stenotrophomonas maltophilia and Pseudomonas aeruginosa and marked radiological deterioration in BE. She was found to have a low serum IgG and IgM levels almost certainly as a complication of Rituximab. Immunoglobulin replacement therapy was instituted and her clinical status has slowly improved.http://www.sciencedirect.com/science/article/pii/S2213007119301649
collection DOAJ
language English
format Article
sources DOAJ
author K. Musameh
C.D. Campbell
R.M. Rutherford
spellingShingle K. Musameh
C.D. Campbell
R.M. Rutherford
Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
Respiratory Medicine Case Reports
author_facet K. Musameh
C.D. Campbell
R.M. Rutherford
author_sort K. Musameh
title Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_short Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_full Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_fullStr Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_full_unstemmed Marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with Rituximab
title_sort marked deterioration in rheumatoid arthritis associated bronchiectasis following treatment with rituximab
publisher Elsevier
series Respiratory Medicine Case Reports
issn 2213-0071
publishDate 2019-01-01
description We report a 67 year old lady with Rheumatoid Arthritis (RA) and mild bronchiectasis (BE) whose treatment was escalated to Rituximab. Nine months after commencing Rituximab her lung sepsis worsened dramatically with repeated hospitalization, new sputum isolation of Stenotrophomonas maltophilia and Pseudomonas aeruginosa and marked radiological deterioration in BE. She was found to have a low serum IgG and IgM levels almost certainly as a complication of Rituximab. Immunoglobulin replacement therapy was instituted and her clinical status has slowly improved.
url http://www.sciencedirect.com/science/article/pii/S2213007119301649
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AT cdcampbell markeddeteriorationinrheumatoidarthritisassociatedbronchiectasisfollowingtreatmentwithrituximab
AT rmrutherford markeddeteriorationinrheumatoidarthritisassociatedbronchiectasisfollowingtreatmentwithrituximab
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