Influence of PD-L1 gene polymorphism on clinicopathological characteristics and clinical prognosis quality of patients with esophageal cancer

• Main Authors: Xiao-Ting Wu, Su-Juan Fei
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2021-02-01
• Series: Journal of Hainan Medical University
• Subjects: pd-l1; gene polymorphism; esophageal cancer; pathological features; prognosis
• Online Access: http://www.hnykdxxb.com/PDF/202104/06.pdf

Objective: To investigate the effect of programmed death-ligand 1 (PD-L1) gene polymorphism on pathological characteristics and clinical prognosis quality in patients with esophageal cancer. Methods: 86 patients with esophageal cancer treated in our hospital from January 2014 to January 2017 were selected as the observation group, and 100 healthy patients were selected as the control group during the same period. The single nucleotide polymorphisms of rs2890658, rs17718883, rs2297136 and rs4143185 at different sites were determined .And the impact of PD-L1 gene polymorphism on pathological features and prognosis of esophageal cancer were analyzed. Results: The observation group finally completed 84 cases, and the control group included 99 cases. There were differences between the observation group and the control group in the PD-L1 different genetic locus rs17718883, rs2890658, rs2297136 (P<0.05). The PD-L1 locus rs17718883 was related to the pathological type and degree of differentiation of esophageal cancer, the difference was statistically significant (P<0.05), rs2890658 was related to the degree of differentiation of esophageal cancer, the difference was statistically significant (P<0.05). Log-rank test showed that the genotype of rs17718883 in patients with esophageal cancer was related to prognostic survival, and the difference was statistically significant (P<0.05). Cox proportional hazards model analysis showed that age, degree of differentiation, lymph node metastasis, and rs17718883 genotype were independent factors in the prognosis of patients with esophageal cancer, and the difference was statistically significant (P<0.05). Conclusion: The polymorphisms of rs17718883 and rs2890658 loci of PD-L1 gene have an impact on the clinicopathological characteristics of patients with esophageal cancer, and the polymorphisms of rs17718883 locus of PD-L1 gene have an impact on the clinical prognosis quality.