Investigating the effects of Pirfenidone on TGF-β1 stimulated non-SMAD signaling pathways in Dupuytren’s disease -derived fibroblasts

Investigating the effects of Pirfenidone on TGF-β1 stimulated non-SMAD signaling pathways in Dupuytren’s disease -derived fibroblasts

Abstract Background Dupuytren’s disease (DD) is a progressive, debilitating condition of the hand that can eventually cause contractures of the affected fingers. Transforming growth factor- β1 (TGF-β1) has been reported to play a key role in DD pathology. Increased expression of TGF-β1 has shown to...

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Bibliographic Details
Main Authors: Chaoming Zhou, Yael Zeldin, Mark E. Baratz, Sandeep Kathju, Latha Satish
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Musculoskeletal Disorders
Subjects:
Dupuytren’s contracture
Palmar fascia fibrosis
Carpal tunnel
AKT
ERK1/2
p38MAPK and myosin light chain (MLC)
Online Access:http://link.springer.com/article/10.1186/s12891-019-2486-3

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http://link.springer.com/article/10.1186/s12891-019-2486-3

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