Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells

Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells

Abstract Background The mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2) inhibitor trametinib has shown promising therapeutic effects on melanoma, but its efficacy on colorectal cancer (CRC) is limited. Synthetic lethality arises with a combination of two or more separate gene mu...

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Bibliographic Details
Main Authors: Rong Geng, Xin Tan, Zhixiang Zuo, Jiangxue Wu, Zhizhong Pan, Wei Shi, Ranyi Liu, Chen Yao, Gaoyuan Wang, Jiaxin Lin, Lin Qiu, Wenlin Huang, Shuai Chen
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Chinese Journal of Cancer
Subjects:
Synthetic lethal
Colorectal cancer
Ring finger protein 183
Mitogen-activated extracellular signal-regulated kinase 1/2
Trametinib
Online Access:http://link.springer.com/article/10.1186/s40880-017-0228-1

Internet

http://link.springer.com/article/10.1186/s40880-017-0228-1

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