Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant Braf<sup>V600E</sup> Melanoma

Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant Braf<sup>V600E</sup> Melanoma

Melanoma patients harboring the BRAF<sup>V600E</sup> mutation are treated with vemurafenib. Almost all of them ultimately acquire resistance, leading to disease progression. Here, we find that a small molecule from a marine sponge, panicein A hydroquinone (PAH), overcomes resistance of B...

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Bibliographic Details
Main Authors: Laurie Signetti, Nelli Elizarov, Méliné Simsir, Agnès Paquet, Dominique Douguet, Fabien Labbal, Delphine Debayle, Audrey Di Giorgio, Valérie Biou, Christophe Girard, Maria Duca, Lionel Bretillon, Corine Bertolotto, Bernard Verrier, Stéphane Azoulay, Isabelle Mus-Veteau
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
Patched
melanoma
vemurafenib
chemotherapy resistance: drug efflux
new therapeutic lead
Online Access:https://www.mdpi.com/2072-6694/12/6/1500

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