Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy

Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy

Glomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, e...

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Main Authors: Janina Müller-Deile, Mario Schiffer
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Pregnancy
Online Access:http://dx.doi.org/10.1155/2011/176973
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spelling doaj-322800a6d68e46e9be4cb971cc0ce1412020-11-25T00:54:07ZengHindawi LimitedJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/176973176973Renal Involvement in Preeclampsia: Similarities to VEGF Ablation TherapyJanina Müller-Deile0Mario Schiffer1Division of Nephrology and Hypertension, Department of Medicine, IFB-TX Hannover, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, GermanyDivision of Nephrology and Hypertension, Department of Medicine, IFB-TX Hannover, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, GermanyGlomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, edema, glomerular capillary endotheliosis, and thrombotic microangiopathy. At least the renal signs, symptoms, and other evidence can sufficiently be explained by reduced VEGF levels. The aim of this paper was to summarize our pathophysiological understanding of the renal involvement of preeclampsia and point out similarities to the renal side effects of VEGF-ablation therapy.http://dx.doi.org/10.1155/2011/176973
collection DOAJ
language English
format Article
sources DOAJ
author Janina Müller-Deile
Mario Schiffer
spellingShingle Janina Müller-Deile
Mario Schiffer
Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy
Journal of Pregnancy
author_facet Janina Müller-Deile
Mario Schiffer
author_sort Janina Müller-Deile
title Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy
title_short Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy
title_full Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy
title_fullStr Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy
title_full_unstemmed Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy
title_sort renal involvement in preeclampsia: similarities to vegf ablation therapy
publisher Hindawi Limited
series Journal of Pregnancy
issn 2090-2727
2090-2735
publishDate 2011-01-01
description Glomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, edema, glomerular capillary endotheliosis, and thrombotic microangiopathy. At least the renal signs, symptoms, and other evidence can sufficiently be explained by reduced VEGF levels. The aim of this paper was to summarize our pathophysiological understanding of the renal involvement of preeclampsia and point out similarities to the renal side effects of VEGF-ablation therapy.
url http://dx.doi.org/10.1155/2011/176973
work_keys_str_mv AT janinamullerdeile renalinvolvementinpreeclampsiasimilaritiestovegfablationtherapy
AT marioschiffer renalinvolvementinpreeclampsiasimilaritiestovegfablationtherapy
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