Giant cell tumor stromal cells: osteoblast lineage-derived cells secrete IL-6 and IL-10 for M2 macrophages polarization

Giant cell tumor stromal cells: osteoblast lineage-derived cells secrete IL-6 and IL-10 for M2 macrophages polarization

Background The giant cell tumor (GCT) is a benign tumor which consists of three types cells: mononuclear histiocytic cells (MNHCs), multinuclear giant cells (MNGCs), and GCT stromal cells (GCTSCs). Numerous studies claim that GCTSCs have mesenchymal stem cells (MSCs) characters and play an important...

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Bibliographic Details
Main Authors: Kuan Yang, Lihui Bao, Xiaoning He, Wanmin Zhao, Dongdong Fei, Bei Li, Yang Xue, Zhiwei Dong
Format: Article
Language:English
Published: PeerJ Inc. 2020-08-01
Series:PeerJ
Subjects:
Giant cell tumor stromal cells
Macrophages
Polarization
Interleukin-6
Interleukin-10
Online Access:https://peerj.com/articles/9748.pdf

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