Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.

Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.

The aberrant expression of microRNAs (miRNAs) is associated with colorectal carcinogenesis, but the underlying mechanisms are not clear. This study showed that the miRNA-27a (miR-27a) was significantly reduced in colorectal cancer tissues and colorectal cancer cell lines, and that the reduced miR-27...

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Main Authors: Yonghua Bao, Zhiguo Chen, Yongchen Guo, Yansheng Feng, Zexin Li, Wenliang Han, Jianguo Wang, Weixing Zhao, Yunjuan Jiao, Kai Li, Qian Wang, Jiaqi Wang, Huijuan Zhang, Liang Wang, Wancai Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4148394?pdf=render

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