Improving bioavailability and anthelmintic activity of albendazole by preparing albendazole-cyclodextrin complexes

Improving bioavailability and anthelmintic activity of albendazole by preparing albendazole-cyclodextrin complexes

The bioavailability and anthelmintic activity of albendazole-cyclodextrin complexes (ABZ-CDC) compared to albendazole suspensions in carboxymethylcellulose (ABZ-CMC) was assessed in a mouse model for Trichinella infections. Swiss CD-1 mice experimentally infected with T. spiralis were treated with b...

Full description

Bibliographic Details
Main Authors: García-Rodriguez J.J., Torrado J., Bolás F.
Format: Article
Language:English
Published: EDP Sciences 2001-06-01
Series:Parasite
Subjects:
albendazole
bioavailability
Trichinella
cyclodextrins
Online Access:http://dx.doi.org/10.1051/parasite/200108s2188
Description
Summary:The bioavailability and anthelmintic activity of albendazole-cyclodextrin complexes (ABZ-CDC) compared to albendazole suspensions in carboxymethylcellulose (ABZ-CMC) was assessed in a mouse model for Trichinella infections. Swiss CD-1 mice experimentally infected with T. spiralis were treated with both formulations against enteral (adult worms) and parenteral (migrating and encysted larvae). Oral bioavailability was assessed in age matched mice treated with 50 mg/kg of both formulations. The anthelmintic effects and plasma concentration of the active metabolite albendazole-sulphoxide (ABZSO) enantiomer (–) were significantly increased following administration of ABZ-CDC in relation to ABZ-CMC.
ISSN:1252-607X
1776-1042

Similar Items