From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology

From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology

Patients with inflammatory bowel disease have an increased risk of developing colorectal cancer, and this risk is related to disease duration, extent, and cumulative inflammation burden. Carcinogenesis follows the principles of Darwinian evolution, whereby somatic cells acquire genomic alterations t...

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Bibliographic Details
Main Authors: Ibrahim Al Bakir, Kit Curtius, Trevor A. Graham
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease (IBD)
colorectal cancer
cancer evolution
risk stratification
biomarker development
surveillance colonoscopy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02368/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02368/full

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