The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α

The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α

The complexity and multi-target feature of natural compounds have made it difficult to elucidate their mechanism of action (MoA), which hindered the development of lead anticancer compounds to some extent. In this study, we applied RNA-Seq and GSEA transcriptome analysis to rapidly and efficiently e...

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Bibliographic Details
Main Authors: Zhaoqing Zheng, Man Wu, Juan Zhang, Wenwei Fu, Naihan Xu, Yuanzhi Lao, Lan Lin, Hongxi Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Oncology
Subjects:
neobractatin
cell cycle
E2F1
GADD45α
RNA-Seq
GSEA
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00654/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00654/full

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