Reaction of aryne with aza-Morita–Baylis–Hillman adducts: Synthesis of 4-quinolones and N-arylation products

Reaction of aryne with aza-Morita–Baylis–Hillman adducts: Synthesis of 4-quinolones and N-arylation products

The reaction of aryne with aza-Morita–Baylis–Hillman (aza-MBH) adducts has been studied. Aryne reacts with aza-MBH adducts through a cascade insertion–cyclization–ene reaction to produce 4-quinolones in 18–44% yields; meanwhile, aza-MBH adducts undergo N-insertion reaction with aryne to afford N-ary...

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Bibliographic Details
Main Authors: Li-Li Liu, Zhi-Juan Li, Cheng-Zhi Gu, Lin He, Bin Dai
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Journal of Saudi Chemical Society
Subjects:
Aryne
Aza-Morita–Baylis–Hillman adducts
4-Quinolone
N-Arylation
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610316300746
Description
Summary:The reaction of aryne with aza-Morita–Baylis–Hillman (aza-MBH) adducts has been studied. Aryne reacts with aza-MBH adducts through a cascade insertion–cyclization–ene reaction to produce 4-quinolones in 18–44% yields; meanwhile, aza-MBH adducts undergo N-insertion reaction with aryne to afford N-arylation products in 27–77% yields.
ISSN:1319-6103

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