Full-length human GLP-1 receptor structure without orthosteric ligands
Glucagon-like peptide-1 receptor (GLP-1R) plays an important role in glucose homeostasis and treatment of type 2 diabetes. Here authors report the peptide-free crystal structure of human GLP-1R in an inactive state which reveals a unique closed conformation of the extracellular domain.
Bibliographic Details
| Main Authors: |
Fan Wu,
Linlin Yang,
Kaini Hang,
Mette Laursen,
Lijie Wu,
Gye Won Han,
Qiansheng Ren,
Nikolaj Kulahin Roed,
Guangyao Lin,
Michael A. Hanson,
Hualiang Jiang,
Ming-Wei Wang,
Steffen Reedtz-Runge,
Gaojie Song,
Raymond C. Stevens |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14934-5
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