Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients

Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients

Mesenchymal stem cells (MSCs) have a potently immunosuppressive capacity in both innate and adaptive immune responses. Consequently, MSCs transplantation has emerged as a potential beneficial therapy for autoimmune diseases even though the mechanisms underlying the immunomodulatory activity of MSCs...

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Bibliographic Details
Main Authors: Rui-Juan Cheng, An-Ji Xiong, Yan-Hong Li, Shu-Yue Pan, Qiu-Ping Zhang, Yi Zhao, Yi Liu, Tony N. Marion
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
systemic lupus erythematosus
mesenchymal stem cells
dysfunction
senescence
immunoregulatory
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00285/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00285/full

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