Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells

Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells

ABSTRACT: Fourteen chemical agents used in dental practice were assessed for their cell-transforming activity using the Syrian hamster embryo (SHE) cell transformation assay system. The cell-transforming activity was quantitatively assessed by the frequency of morphological transformation (MT) in SH...

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Main Authors: Fusae Yamaguchi, Takeki Tsutsui
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319325666
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spelling doaj-31ea424aff024fada615e0e7ff1be3ab2020-11-25T01:07:23ZengElsevierJournal of Pharmacological Sciences1347-86132003-01-01934497500Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo CellsFusae Yamaguchi0Takeki Tsutsui1Department of Pharmacology, The Nippon Dental University, School of Dentistry at Tokyo, 1-9-21 Fujimi, Chiyoda-ku, Tokyo 102-8159, JapanDepartment of Pharmacology, The Nippon Dental University, School of Dentistry at Tokyo, 1-9-21 Fujimi, Chiyoda-ku, Tokyo 102-8159, JapanABSTRACT: Fourteen chemical agents used in dental practice were assessed for their cell-transforming activity using the Syrian hamster embryo (SHE) cell transformation assay system. The cell-transforming activity was quantitatively assessed by the frequency of morphological transformation (MT) in SHE cells induced by these agents. MT was induced by m-cresol, guaiacol, formaldehyde, sodium hypochlorite, hydrogen peroxide, sodium arsenite, acid fuchsin, and basic fuchsin, but not by p-chlorophenol, p-phenolsulfonic acid, glutaraldehyde, and erythrosine B. Iodine and chlorhexidine exhibited positive and pseudopositive responses, respectively. The chemical agents exhibiting a negative or pseudopositive response neither induced nor enhanced MT even in the presence of exogenous metabolic activation.http://www.sciencedirect.com/science/article/pii/S1347861319325666
collection DOAJ
language English
format Article
sources DOAJ
author Fusae Yamaguchi
Takeki Tsutsui
spellingShingle Fusae Yamaguchi
Takeki Tsutsui
Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells
Journal of Pharmacological Sciences
author_facet Fusae Yamaguchi
Takeki Tsutsui
author_sort Fusae Yamaguchi
title Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells
title_short Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells
title_full Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells
title_fullStr Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells
title_full_unstemmed Cell-Transforming Activity of Fourteen Chemical Agents Used in Dental Practice in Syrian Hamster Embryo Cells
title_sort cell-transforming activity of fourteen chemical agents used in dental practice in syrian hamster embryo cells
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2003-01-01
description ABSTRACT: Fourteen chemical agents used in dental practice were assessed for their cell-transforming activity using the Syrian hamster embryo (SHE) cell transformation assay system. The cell-transforming activity was quantitatively assessed by the frequency of morphological transformation (MT) in SHE cells induced by these agents. MT was induced by m-cresol, guaiacol, formaldehyde, sodium hypochlorite, hydrogen peroxide, sodium arsenite, acid fuchsin, and basic fuchsin, but not by p-chlorophenol, p-phenolsulfonic acid, glutaraldehyde, and erythrosine B. Iodine and chlorhexidine exhibited positive and pseudopositive responses, respectively. The chemical agents exhibiting a negative or pseudopositive response neither induced nor enhanced MT even in the presence of exogenous metabolic activation.
url http://www.sciencedirect.com/science/article/pii/S1347861319325666
work_keys_str_mv AT fusaeyamaguchi celltransformingactivityoffourteenchemicalagentsusedindentalpracticeinsyrianhamsterembryocells
AT takekitsutsui celltransformingactivityoffourteenchemicalagentsusedindentalpracticeinsyrianhamsterembryocells
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