Mechanism of prion propagation: amyloid growth occurs by monomer addition.
Abundant nonfibrillar oligomeric intermediates are a common feature of amyloid formation, and these oligomers, rather than the final fibers, have been suggested to be the toxic species in some amyloid diseases. Whether such oligomers are critical intermediates for fiber assembly or form in an altern...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2004-10-01
|
| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC517824?pdf=render |