Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions

Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions

The catalytic ability of ZrO2/SO42- to promote solventless three-componentcondensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethylacetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid...

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Main Authors: Guillermo Negrón-Silva, Eduardo González-Zamora, Victor H. Lara-Corona, Leticia Lomas-Romero, Deyanira Angeles-Beltrán
Format: Article
Language:English
Published: MDPI AG 2006-10-01
Series:Molecules
Subjects:
Biginelli reaction
Hantzsch reaction
multicomponent reactions
1
4- dihydropyridines
dihydropyrimidinones
solventless reactions.
Online Access:http://www.mdpi.com/1420-3049/11/10/731/
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spelling doaj-31dc14ee9e9347dda4b0d0fcfc0cad712020-11-24T23:46:46ZengMDPI AGMolecules1420-30492006-10-01111073173810.3390/11100731Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch ReactionsGuillermo Negrón-SilvaEduardo González-ZamoraVictor H. Lara-CoronaLeticia Lomas-RomeroDeyanira Angeles-BeltránThe catalytic ability of ZrO2/SO42- to promote solventless three-componentcondensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethylacetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the samereactants but different temperature conditions. The sulfated zirconia catalyst can berecovered and recycled in subsequent reactions with a gradual decrease of activity.http://www.mdpi.com/1420-3049/11/10/731/Biginelli reactionHantzsch reactionmulticomponent reactions14- dihydropyridinesdihydropyrimidinonessolventless reactions.
collection DOAJ
language English
format Article
sources DOAJ
author Guillermo Negrón-Silva
Eduardo González-Zamora
Victor H. Lara-Corona
Leticia Lomas-Romero
Deyanira Angeles-Beltrán
spellingShingle Guillermo Negrón-Silva
Eduardo González-Zamora
Victor H. Lara-Corona
Leticia Lomas-Romero
Deyanira Angeles-Beltrán
Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
Molecules
Biginelli reaction
Hantzsch reaction
multicomponent reactions
1
4- dihydropyridines
dihydropyrimidinones
solventless reactions.
author_facet Guillermo Negrón-Silva
Eduardo González-Zamora
Victor H. Lara-Corona
Leticia Lomas-Romero
Deyanira Angeles-Beltrán
author_sort Guillermo Negrón-Silva
title Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
title_short Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
title_full Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
title_fullStr Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
title_full_unstemmed Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
title_sort sulfated zirconia-catalyzed synthesis of 3,4-dihydropyrimidin-2(1h)-ones (dhpms) under solventless conditions: competitive multicomponent biginelli vs. hantzsch reactions
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2006-10-01
description The catalytic ability of ZrO2/SO42- to promote solventless three-componentcondensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethylacetoacetate was studied. Products resulting from Hantzsch and/or Biginelli multi-component reactions are obtained in the presence of solid acid catalysts using the samereactants but different temperature conditions. The sulfated zirconia catalyst can berecovered and recycled in subsequent reactions with a gradual decrease of activity.
topic Biginelli reaction
Hantzsch reaction
multicomponent reactions
1
4- dihydropyridines
dihydropyrimidinones
solventless reactions.
url http://www.mdpi.com/1420-3049/11/10/731/
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