Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs

Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs

Spironolactone, a classical diuretic drug, is used to treat tumor-associated complications in cancer patients. Spironolactone was recently reported to exert anti-cancer effects by suppressing DNA damage repair. However, it currently remains unclear whether spironolactone exerts combinational effects...

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Bibliographic Details
Main Authors: Tomomi Sanomachi, Shuhei Suzuki, Keita Togashi, Asuka Sugai, Shizuka Seino, Masashi Okada, Takashi Yoshioka, Chifumi Kitanaka, Masahiro Yamamoto
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
drug resistance
spironolactone
osimertinib
survivin
xenograft
cancer stem cells
Online Access:https://www.mdpi.com/2072-6694/11/10/1550

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