Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing
A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy o...
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Hindawi Limited
2012-01-01
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2012/843025 |
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doaj-31d8aa6eb9da43e198cf49887b06aae02020-11-24T23:28:36ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882012-01-01201210.1155/2012/843025843025Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound DressingRozaini Mohd Zohdi0Zuki Abu Bakar Zakaria1Norimah Yusof2Noordin Mohamed Mustapha3Muhammad Nazrul Hakim Abdullah4Department of Life Sciences, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, MalaysiaDepartment of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDivision of Agrotechnology and Biosciences, Malaysian Nuclear Agency, Bangi, 43000 Kajang, Selangor, MalaysiaDepartment of Veterinary Microbiology and Pathology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaA novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy on deep partial thickness burn wounds in rats were assessed. Skin samples were taken at 7, 14, 21, and 28 days after burn for histopathological and molecular evaluations. Application of honey hydrogel dressings significantly enhanced (P<0.05) wound closure and accelerated the rate of re-epithelialization as compared to control hydrogel and OpSite film dressing. A significant decrease in inflammatory response was observed in honey hydrogel treated wounds as early as 7 days after burn (P<0.05). Semiquantitative analysis using RT-PCR revealed that treatment with honey hydrogel significantly (P<0.05) suppressed the expression of proinflammatory cytokines (IL-1α, IL-1β, and IL-6). The present study substantiates the potential efficacy of honey hydrogel dressings in accelerating burn wound healing.http://dx.doi.org/10.1155/2012/843025 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rozaini Mohd Zohdi Zuki Abu Bakar Zakaria Norimah Yusof Noordin Mohamed Mustapha Muhammad Nazrul Hakim Abdullah |
spellingShingle |
Rozaini Mohd Zohdi Zuki Abu Bakar Zakaria Norimah Yusof Noordin Mohamed Mustapha Muhammad Nazrul Hakim Abdullah Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing Evidence-Based Complementary and Alternative Medicine |
author_facet |
Rozaini Mohd Zohdi Zuki Abu Bakar Zakaria Norimah Yusof Noordin Mohamed Mustapha Muhammad Nazrul Hakim Abdullah |
author_sort |
Rozaini Mohd Zohdi |
title |
Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing |
title_short |
Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing |
title_full |
Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing |
title_fullStr |
Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing |
title_full_unstemmed |
Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing |
title_sort |
gelam (melaleuca spp.) honey-based hydrogel as burn wound dressing |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2012-01-01 |
description |
A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy). In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy on deep partial thickness burn wounds in rats were assessed. Skin samples were taken at 7, 14, 21, and 28 days after burn for histopathological and molecular evaluations. Application of honey hydrogel dressings significantly enhanced (P<0.05) wound closure and accelerated the rate of re-epithelialization as compared to control hydrogel and OpSite film dressing. A significant decrease in inflammatory response was observed in honey hydrogel treated wounds as early as 7 days after burn (P<0.05). Semiquantitative analysis using RT-PCR revealed that treatment with honey hydrogel significantly (P<0.05) suppressed the expression of proinflammatory cytokines (IL-1α, IL-1β, and IL-6). The present study substantiates the potential efficacy of honey hydrogel dressings in accelerating burn wound healing. |
url |
http://dx.doi.org/10.1155/2012/843025 |
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