Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

The preparation of novel multi-substituted 1,2,3-triazole-modified β-aminocyclohexanecarboxylic acid derivatives in a simple and efficient continuous-flow procedure is reported. The 1,3-dipolar cycloaddition reactions were performed with copper powder as a readily accessible Cu(I) source. Initially,...

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Bibliographic Details
Main Authors:	Sándor B. Ötvös, Ádám Georgiádes, István M. Mándity, Lóránd Kiss, Ferenc Fülöp
Format:	Article
Language:	English
Published:	Beilstein-Institut 2013-07-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	β-amino acids click chemistry continuous-flow copper flow chemistry triazoles
Online Access:	https://doi.org/10.3762/bjoc.9.172

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