An Integrative Analysis Reveals a Central Role of P53 Activation via MDM2 in Zika Virus Infection Induced Cell Death

An Integrative Analysis Reveals a Central Role of P53 Activation via MDM2 in Zika Virus Infection Induced Cell Death

Zika virus (ZIKV) infection is an emerging global threat that is suspected to be associated with fetal microcephaly. However, the molecular mechanisms underlying ZIKV disease pathogenesis in humans remain elusive. Here, we investigated the human protein interaction network associated with ZIKV infec...

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Bibliographic Details
Main Authors: Yue Teng, Shufeng Liu, Xiaocan Guo, Shuxia Liu, Yuan Jin, Tongtong He, Dehua Bi, Pei Zhang, Baihan Lin, Xiaoping An, Dan Feng, Zhiqiang Mi, Yigang Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Zika virus
microcephaly
capsid protein
P53
MDM2
cell death
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00327/full

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