Orchestration of protein acetylation as a toggle for cellular defense and virus replication

Orchestration of protein acetylation as a toggle for cellular defense and virus replication

The dynamics of protein acetylation during infection remains unexplored. Here, Murray et al. characterize spatio-temporal acetylations of both cellular and viral proteins during HCMV infection, providing new functional insights into the host-virus acetylome that might help identify new antiviral tar...

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Bibliographic Details
Main Authors: L. A. Murray, X. Sheng, I. M. Cristea
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07179-w
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spelling doaj-31cf50fe17a34c7da4208250bed5fe522021-05-11T09:33:07ZengNature Publishing GroupNature Communications2041-17232018-11-019111710.1038/s41467-018-07179-wOrchestration of protein acetylation as a toggle for cellular defense and virus replicationL. A. Murray0X. Sheng1I. M. Cristea2Department of Molecular Biology, Princeton University, Lewis Thomas LaboratoryDepartment of Molecular Biology, Princeton University, Lewis Thomas LaboratoryDepartment of Molecular Biology, Princeton University, Lewis Thomas LaboratoryThe dynamics of protein acetylation during infection remains unexplored. Here, Murray et al. characterize spatio-temporal acetylations of both cellular and viral proteins during HCMV infection, providing new functional insights into the host-virus acetylome that might help identify new antiviral targets.https://doi.org/10.1038/s41467-018-07179-w
collection DOAJ
language English
format Article
sources DOAJ
author L. A. Murray
X. Sheng
I. M. Cristea
spellingShingle L. A. Murray
X. Sheng
I. M. Cristea
Orchestration of protein acetylation as a toggle for cellular defense and virus replication
Nature Communications
author_facet L. A. Murray
X. Sheng
I. M. Cristea
author_sort L. A. Murray
title Orchestration of protein acetylation as a toggle for cellular defense and virus replication
title_short Orchestration of protein acetylation as a toggle for cellular defense and virus replication
title_full Orchestration of protein acetylation as a toggle for cellular defense and virus replication
title_fullStr Orchestration of protein acetylation as a toggle for cellular defense and virus replication
title_full_unstemmed Orchestration of protein acetylation as a toggle for cellular defense and virus replication
title_sort orchestration of protein acetylation as a toggle for cellular defense and virus replication
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description The dynamics of protein acetylation during infection remains unexplored. Here, Murray et al. characterize spatio-temporal acetylations of both cellular and viral proteins during HCMV infection, providing new functional insights into the host-virus acetylome that might help identify new antiviral targets.
url https://doi.org/10.1038/s41467-018-07179-w
work_keys_str_mv AT lamurray orchestrationofproteinacetylationasatoggleforcellulardefenseandvirusreplication
AT xsheng orchestrationofproteinacetylationasatoggleforcellulardefenseandvirusreplication
AT imcristea orchestrationofproteinacetylationasatoggleforcellulardefenseandvirusreplication
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