Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis

Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis

A convenient synthetic method has been developed for accessing 2,6-dialkynyl-3,5-dichloropyridine derivatives in acceptable to good yields. The methodology involved ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis. A variety of terminal alkynes...

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Main Authors: Sallagundla Bhavani, Dandela Rambabu, Mandava Venkata Basaveswara Rao, Manojit Pal
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Arabian Journal of Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535216300570
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spelling doaj-31cab8d6eaa1493ba88137ad1e67bc4c2020-11-25T02:45:28ZengElsevierArabian Journal of Chemistry1878-53522019-12-0112841894196Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysisSallagundla Bhavani0Dandela Rambabu1Mandava Venkata Basaveswara Rao2Manojit Pal3Department of Chemistry, K. L. University, Vaddeswaram, Guntur 522502, Andhra Pradesh, IndiaDepartment of Chemistry and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be’er-Sheva 84105, IsraelDepartment of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India; Corresponding authors. Tel.: +91 40 6657 1500.Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India; Corresponding authors. Tel.: +91 40 6657 1500.A convenient synthetic method has been developed for accessing 2,6-dialkynyl-3,5-dichloropyridine derivatives in acceptable to good yields. The methodology involved ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis. A variety of terminal alkynes were employed in this CC coupling reaction to afford the corresponding 2,6-dialkynyl-3,5-dichloropyridine derivatives. Keywords: Pyridine, Alkynes, Pd/C, Ultrasoundhttp://www.sciencedirect.com/science/article/pii/S1878535216300570
collection DOAJ
language English
format Article
sources DOAJ
author Sallagundla Bhavani
Dandela Rambabu
Mandava Venkata Basaveswara Rao
Manojit Pal
spellingShingle Sallagundla Bhavani
Dandela Rambabu
Mandava Venkata Basaveswara Rao
Manojit Pal
Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis
Arabian Journal of Chemistry
author_facet Sallagundla Bhavani
Dandela Rambabu
Mandava Venkata Basaveswara Rao
Manojit Pal
author_sort Sallagundla Bhavani
title Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis
title_short Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis
title_full Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis
title_fullStr Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis
title_full_unstemmed Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis
title_sort ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under pd/ccu catalysis
publisher Elsevier
series Arabian Journal of Chemistry
issn 1878-5352
publishDate 2019-12-01
description A convenient synthetic method has been developed for accessing 2,6-dialkynyl-3,5-dichloropyridine derivatives in acceptable to good yields. The methodology involved ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis. A variety of terminal alkynes were employed in this CC coupling reaction to afford the corresponding 2,6-dialkynyl-3,5-dichloropyridine derivatives. Keywords: Pyridine, Alkynes, Pd/C, Ultrasound
url http://www.sciencedirect.com/science/article/pii/S1878535216300570
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AT dandelarambabu ultrasoundassistedsiteselectivealkynylationof2356tetrachloropyridinesunderpdccucatalysis
AT mandavavenkatabasaveswararao ultrasoundassistedsiteselectivealkynylationof2356tetrachloropyridinesunderpdccucatalysis
AT manojitpal ultrasoundassistedsiteselectivealkynylationof2356tetrachloropyridinesunderpdccucatalysis
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