Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats
The purpose of the research is to assess the acute oral toxicity of the drug Altrik-Extra in mice and rats, to determine its hazard class depending on the degree of exposure to animals.Materials and methods. White outbred mice and rats were used in the experiment. In the study of acute oral toxicity...
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Federal Scientific Centre VIEV
2019-12-01
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| Series: | Российский паразитологический журнал |
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| Online Access: | https://vniigis.elpub.ru/jour/article/view/530 |
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doaj-31ca681292e142a0b48828b8ed3923022021-09-16T19:27:11ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432019-12-01134778210.31016/1998-8435-2019-13-4-77-82524Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and RatsE. V. Lagereva0V. E. Abramov1All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"The purpose of the research is to assess the acute oral toxicity of the drug Altrik-Extra in mice and rats, to determine its hazard class depending on the degree of exposure to animals.Materials and methods. White outbred mice and rats were used in the experiment. In the study of acute oral toxicity, conventional techniques were used.Results and discussion. Average lethal doses of LD50 were established when administered orally to laboratory animals. For mice, LD50 was more than 5986 mg/kg. Thus, according to the generally accepted hygienic classification (GOST 12.1.007-76), Altrick- Extra belongs to the 4th hazard class (low-hazard substances). In the study of acute oral toxicity in rats, LD50 was 3 103.1±748.5 mg/kg (confidence interval boundaries 2 354.6÷3 851.5 mg/kg). Therefore, in accordance with GOST 12.1.007-76, the studied drug belongs to the 3rd class of danger (moderately dangerous substances).https://vniigis.elpub.ru/jour/article/view/530altrick-extraalbendazoletriclabendazoleacute toxicitymicerats |
| collection |
DOAJ |
| language |
Russian |
| format |
Article |
| sources |
DOAJ |
| author |
E. V. Lagereva V. E. Abramov |
| spellingShingle |
E. V. Lagereva V. E. Abramov Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats Российский паразитологический журнал altrick-extra albendazole triclabendazole acute toxicity mice rats |
| author_facet |
E. V. Lagereva V. E. Abramov |
| author_sort |
E. V. Lagereva |
| title |
Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats |
| title_short |
Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats |
| title_full |
Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats |
| title_fullStr |
Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats |
| title_full_unstemmed |
Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats |
| title_sort |
evaluation of acute oral toxicity of supramolecular complex based on albendazole and triclabendazole – altrick-extra in laboratory outbred mice and rats |
| publisher |
Federal Scientific Centre VIEV |
| series |
Российский паразитологический журнал |
| issn |
1998-8435 2541-7843 |
| publishDate |
2019-12-01 |
| description |
The purpose of the research is to assess the acute oral toxicity of the drug Altrik-Extra in mice and rats, to determine its hazard class depending on the degree of exposure to animals.Materials and methods. White outbred mice and rats were used in the experiment. In the study of acute oral toxicity, conventional techniques were used.Results and discussion. Average lethal doses of LD50 were established when administered orally to laboratory animals. For mice, LD50 was more than 5986 mg/kg. Thus, according to the generally accepted hygienic classification (GOST 12.1.007-76), Altrick- Extra belongs to the 4th hazard class (low-hazard substances). In the study of acute oral toxicity in rats, LD50 was 3 103.1±748.5 mg/kg (confidence interval boundaries 2 354.6÷3 851.5 mg/kg). Therefore, in accordance with GOST 12.1.007-76, the studied drug belongs to the 3rd class of danger (moderately dangerous substances). |
| topic |
altrick-extra albendazole triclabendazole acute toxicity mice rats |
| url |
https://vniigis.elpub.ru/jour/article/view/530 |
| work_keys_str_mv |
AT evlagereva evaluationofacuteoraltoxicityofsupramolecularcomplexbasedonalbendazoleandtriclabendazolealtrickextrainlaboratoryoutbredmiceandrats AT veabramov evaluationofacuteoraltoxicityofsupramolecularcomplexbasedonalbendazoleandtriclabendazolealtrickextrainlaboratoryoutbredmiceandrats |
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1717377965909606400 |