Intraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian Prion.

Intraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian Prion.

The prion hypothesis postulates that the infectious agent in transmissible spongiform encephalopathies (TSEs) is an unorthodox protein conformation based agent. Recent successes in generating mammalian prions in vitro with bacterially expressed recombinant prion protein provide strong support for th...

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Bibliographic Details
Main Authors: Xinhe Wang, Gillian McGovern, Yi Zhang, Fei Wang, Liang Zha, Martin Jeffrey, Jiyan Ma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4489884?pdf=render

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