Expression weighted cell type enrichments reveal genetic and cellular nature of major brain disorders

The cell types that trigger the primary pathology in many brain diseases remain largely unknown. One route to understanding the primary pathological cell type for a particular disease is to identify the cells expressing susceptibility genes. Although this is straightforward for monogenic conditions...

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Bibliographic Details
Main Authors: Nathan Gerald Skene, Seth G N Grant
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00016/full